imo I would still be cautious. SR accounted for ~300-400 million in revenue a year for bitcoins. Much of which was from fresh money being brought in by customers. I don't know of anything else in the same stratosphere in terms of bringing in money into the network. SR was/is a big deal. Will there be other sites to take its place? Sure.. but to what extent they will fill that void remains to be seen. Also will customers/vendors of these sites be weary about jumping back into this market?
The same as when they close a file sharing site. They really like mopping the floor with the water running and then wonder why they're never finished.
There will be new sites like SR, but never as popular as SR for the next time. And also the risk now is even higher to start a portal like Silkroad, after Gov closed SR.
Filesharing is different, because it depends on laws of a country.So when the server is in Africa, Gov of the U.S can do nothing against it, as long as they don´t have american friendly providers there. That is the difference.