Does anyone have any idea?
I have a lot idea.
How if you give us more info about your devices first (people has asking above, I'm just adding some).
Let's start with:
Motherboard type and series then,PSUs wattage (Brands, Efficiency rates if possible),OS you are using,Driver version,Powering scheme. As much as you can tell us.
Have you tried with 2 X R9 on that mobo (380x + 390)? What else have you tried? I suspected that was less power and or driver issue.
If you tell us more info, we can help you more.