A GTX 1080 ti is VERY cost effective on merged folding - probably the best card to use for that - *IF* you have a folding-optimized rig.
On ZEC, they're very close on hash/watt vs ANY member of the GTX 10xx family when all are operated at "most efficient" settings, and they've usually been very close on a "rig-level" basis on hash/$.
THE most cost effective, no - but not all that far off it and some folks are willing to pay a small premium for the higher rig density they offer (and lower time spent managing those rigs on LARGE farms).
The numbers probably vary if you're not in the US - some areas might charge more of a "premium" for the higher-end cards than we usually see here.
They are cool cards for sure but for mining purposes, the only thing that matters is cost efficiency and they fail pretty hard there.