When you get sufficient profit
I depends upon where you invest. It is very important, we have many coins to invest, and some shitcoins will have more potential, and it will make you invest. Don't go for those coins. Always concentrate on top 20 coins. You are looking for 30% to 40% profit means you should invest in high potential coins. I will look for cheap price coins and high potential, and I have the patience to wait until the price reach my target.