I did run a geccoscience Compaq, 2 u2's and a gc3355 in scrypt mode from a single driver in the past... So it's defenately possible... If I remember correctly, I just compiled cgminer for each device individually and ran them separately, but I'm not completely sure anymore... The way I see it, you already bought the hardware, so there is no harm in trying anyways, just compile cgminer and try if you get it to work..

Good luck