So... I've been having the same problem for two weeks. I set up my miner, everything is running great, and then I launch Claymore, it loads for about 15 seconds and then the all hell breaks loose. The fans all turn to 100% and it sounds like a jet engine, then Claymore gives me and error about not being able to read temperature, and then my entire system crashes. Blue screen of "something went wrong. need to restart". Sometimes I get a warning saying "the application claymoreminer.... has been blocked from accessing graphics hardware". I have to reset the rig by holding down the power button. Sometimes when it loads back up I only have 3 graphics cards recognized and I basically have to reinstall windows because I cant get it to re-recognize the cards.

So far, here are a bunch of steps I've taken
PCIE lanes to Gen1
Disable CSM support
Virtual memory size to 24gb
Hi power mode on power settings and system settings
Reinstalled GPU drivers (8-10 times) directly from Nvidia
Turned off windows updates
Turned off windows defender (which is odd because it still blocks my miner when defender is off)
Placed my miner in an exception folder on windows defender
Switched to a different miner (ZCash excavator)
Reinstalled windows (4 times)
Reinstalled graphics cards 1 at a time
Purchased a new motherboard (thought it was the issue)
Turn off all overclocks
Updated motherboard bios

On both motherboards I have had the exact same issue. I think it's related to the nvidia drivers? Anyone PLEASE help.

My setup is
Gigabyte GA-270p-d3 motherboard
G3900 CPU
4gb DDR4
120gb m.2 SSD
x6 Asus gtx 1060 6gb
1000w rosewill power supply

I'm so frustrated I don't even know where to go next. Willing to send a few days worth of mining to whoever can figure this out. I'm desperate