Self esteem suffering from depression fear about facing reality. Some people try to fight reality by thier expectations in life and thats not how it works base on thier own expectations. Some people being rejected by there looks and thier blame them self and Some people Are lack of ability to handle failures.
The ability to handle failures is something that comes with experience. But if the parents raise their children in such a way that they never face failure, then in the future they may not be having the ability to cope with them. I have noticed this a few times in my society.