What's a good failover?
I currently have it in order:
:3333
:80
:81
but the :81 is showing dead.
Just to explain the ports

They're all the same node - so that wont help for a failover.
The extra ports are for people who have difficulty connecting to port 3333 due to being blocked on their network.
e.g. 80 or 443 should be open on most networks since thats Web and Web SSL.
and I always throw in 81 and 8080 so there's a couple more choices to try.
Use a different node for pool2
Use your closest node for pool1 and then the next closest one for pool2
Is the main "stratum+tcp://stratum.kano.is:3333" node US based? I've been using the New York node "stratum+tcp://nya.kano.is:3333" but I'm closer to the West Coast.