Today almost all coins that I was HODLing came back into profit zone, so I managed to close old trades.
I do not risk something, which I can't afford to lose. Crypto markets can wipe all your account away very fast.
And when you decide not to HODL any more what do you do? Convert to BTC, or USD? What is your stable currency. What do you convert your profit into.
As soon as price back in profit zone - I close the hanging trade. The goal is to take profit from growing coins as fast as possible and re-enter the position if conditions are right.
I hold BTC, USD and ETH in equal parts. If I close the trades on BTC pairs I leave the profit in BTC. I can re-balance my deposits if one of the parts shrinks.