Security is a big issue with altcoins, especially those build on blockchains other than bitcoin and ethereum. Computational power is what safeguards blockchains and its a limited resource, so some blockchains could be easily compromised using a 51% attack.
The security of smart contracts is also an issue. Recent research shows that 30K deployed smart contracts have bugs and can be exploited by hackers. That's why we a launching Aegis Platform, an all-in-one smart contract auditing tool offering triple audits (expert audits, automated audits and bug bounty audits) as well as certification to help investors know that a particular contract has been scanned for all known vulnerabilities and bugs.