Yes, there is a lot of Bitcoin that is lost forever specially in the early year of its creation but remember back then the price was $.001 and they can mine Bitcoin very easily. People who have mined Bitcoin was basically not that concern on their mined Bitcoin but nowadays since a Bitcoin costs a fortune people who actually have it are protecting it with their lives. People are very careful now with their wallets. With that said I do not think there will come a time that the lost Bitcoin will not effect us.