Like any good investment you dollar cost average in, and do the same going out.
When you have a basis for your BTC of about $100 per (assuming you bought some) and its $850 today, if you don't start slowly getting out then you are just a greedy bitch who doesn't know what they are doing.
I have X in cold storage and now I just start selling when the price is favorable every few days.
You don't get the "R" in ROI unless you take some profit.
What you seem to be missing is that bitcoin IS profit.
It is money, yes? What are you counting as profit, the endless streams of (waste)paper being printed by governments?
Or good hard cryptocoin?
-MarkM-