Another peculiarity of the BTC-e ticketing system, if they don't respond to you in 72 hours, and that you don't ask for help again. An automated robot will send you an email saying:

• "We have not heard back from you in 72 hours and would like to know if you consider this issue to be resolved."
  

Here's the kicker, it goes on to say:

• "Please note that the ticket will automatically be closed within 1 hours if we don't hear back."
  

What this mean is, essentially, as if BTC-e not responding to your tickets is not bad enough, the customers needs to be on stand-by, and whenever they get this email, they need to respond immediately within an hour! This sure is some set up. On the other hand, you can still go in and re-open a ticket later on, but in general there is no response any way, so perhaps there's no difference one way or another.