I was thinking this too. Looking at a long list of ASICS that can be reordered, they all seem to be popping up at points where the increased difficulty in the bitcoin algo would make them next to unprofitable.

I'm thinking I would just build a GPU cluster and mine some SCRYPT based coins. They are apparently ASIC resistant, this should make their difficulty curve less disruptive. I really want to do some real mining as opposed to downright coin purchase. My ideal scenario would be coming up with a solution that scales with corresponding difficulty increase in the altcoin algo while remaining profitable.