Well assuming an investment from a long term point of view, it is most advisable to stick to coins that are pretty established or have a good use case/ fundamental value. I would suggest not looking beyond the top 15-25 coin on cmc. In my opinion the coins that probably has the best use cases are the platform coins/ privacy coins and of course the main pure currency coins.  Of course a case could also be made for dexes, i mean they obviously have massive use case, however its still debatable whether they can succeed on a large scale relative to the centralized exchanges, in an environment where governments will most likely look very unfavourably towards non KYC trading.

Either ways heres my list

BTC
Ether
Monero
Z cash
EOS( though perhaps wait after mainet launch is case it dumps)
NEO
Lisk
Cardano
BNB (best hedge for exposure to a dex as they plan to do a dex in the future and even if they fail its a great exchange)