With some of the recent Love and Hate posts lately, the best thing Bittrex could do would be to add a reputable coin with a great future, like DNR.  It would also bring in a different community of users to Bittrex, benefiting all coins traded on Bittrex. 

I for one would LOVE to have a DNR/USD pairing, and I'm pretty sure I'd be mostly buying DNR for the next 6 months ;-)