I noticed the same thing just now. Rebooted machine (Win7 x64 SP1), started cudaMiner, and the speed was much worse than what it was supposed to be. Also, GPU-Z said that GPU load was only at 78%. Immediately after I started Chrome the GPU load rose to 99% and cudaMiners' speed returned to the expected level. Would be interesting to know what's causing this...
I'd double down on power saving settings, since IIRC, Chrome is hardware accelerated by default on most machines.