Thanks for your feedback, Dirk.  The pool's Algorithm checkboxes should be read-only when that algorithm is already disabled for every device. This is because the software will not attempt to mine that algorithm regardless of the pool setting.  I just tested this situation on one of my systems and I could disable Skein for AHashPool when Skein was still enabled on my GPUs.  As soon as I disabled that algorithm for all the GPUs, I could no longer disable it for the pool as the checkbox was readonly. If you have not disabled Skein on your GPUs, please let me know and I will take a look to see if there may be some other issue involved.

As a side note, I recognize that the pool's read-only algorithm checkboxes should be unchecked to better reflect that these algorithms are already disabled. That change will be in the next version of the software.