The one thing that would be really nice to be able to get happening is to integrate merge mining so we can get some free hash power to reduce the vulnerability of the chain, but I'm not sure what's involved with that exactly. I know several sha256d and scrypt coins based on bitcoin have this, so it might not be so difficult to integrate.
I'm not aware of any multi-algo coins that allow merge mining. DUO would be the first if you could pull this off?