if you anable Two-factor Authentication (2FA) on blockchain.info then your wallet there is really safe .
But the safest wallet ever will be a paper wallet that you lock in any tresor (allö offline)

regards
The Two Factor Authentication is not really safe because it also can be Bypass by the hackers so the paper wallet is the best for the long term holding but the wallet like Ledger Nano S is better for holding the multiple crypto currencies in long term.