Ok. Tried a lot this night. The Problem are the EU server. With EU server 10 - 15% and up to 70%(!!!) invalid shares. Same settings now with the US server (and I´m from Germany) only 1-2% invalid shares. Thats fine for me.
Admin, you should take a look at the EU server!!!
Thanks to all, who tried to help me. Wish I had tried US server first and not after hours of tuning my settings and system - what´s no fun with 4 rigs and 11 GPUs

Thanks!! I've also noted an abnormally high % of invalid shares when mining DOGE in the EU pool. CUDAminer reports 8 % invalid (which is high for me, usually it is below 3 %) and the server reports 33 % invalid. Just changed to us server, up to now 100% valid.