In the spirit of the original list:
- Lyndon LaRouche
- Time travel
- Unicorn disclosure
More seriously:
- Aquifer depletion and water shortages
- Increasing oil prices
- Decreasing renewable energy prices
- Automated warfare
- Climate change
- Additive manufacturing
- The end of Moore's Law and failure-to-materialize of the Technological Singularity*
- Global convergence of material standards of living
Far more speculative, but not impossible and certainly disruptive if they come to pass:
- Molecular manufacturing as in Drexler's Engines of Creation
- Increasing the overall human life span or just finding a way to keep people healthy and productive up until death
- Nuclear war, even a "little" one like between Pakistan and India
*This is more of a refutation of another popular megatrend idea than a trend in itself