Yes it can be hacked because hackers always find new ways to hack. We are required to 2FA to avoid wallet being hacked. I will prefer to use hardware wallets like trezor to have a better experiences on using wallets. Don't use web wallets.
Hackers is always there, because they fined ways to steal money, that is there work. Therefore we have to careful and make our fund safe in all bad people, specially in hackers.
yes, we need to always secure our cryptocurrency wallet so we don't have to afraid and worry from the hacker. once we are not careful with our wallet, we have a big chance to be hacked and we can lose the coins that we have without any chance to get it back. there are many ways to secure our wallet and we need to follow step by step to securing the wallet. besides that, maybe you don't have to use web wallet because I think it's too risky for you especially if you have a big amount.