The best way to keep your bitcoins safe, is to use a hardware wallet that have stronger cryptography that web wallets.
If you store your coins in exchanges you are most likely to lose them, because exchanges receive the most cyber attacks.
The simple and basic way to keep your bitcoin safe and secure by just simply put it in a trusted site so that you can assure your bitcoin is safe. Do not ever try to put it in a exchange because there are some cyber attack and they will steal your bitcoin. Hence, you must use a trusted wallet or you put it in a ledger or simply called as hardware wallet.