It depends on the strength of your portfolio. If you can afford to hodl for long its better not to sell in loss.
On the other hand, you could sell off at any little upward movement, then buy back and sell off with little percent profit. That way you make more than a hodler
This is the most important parameter in trading. You should always be able to hold coins. Because panic and the last money will play a big joke with you and you will get negative emotions.