It's profitable with POS coins such as PIVX, DASH etc. by running a Masternode but you'll have to invest in buying coins first, simply running a node without doing anything won't do you anything.
Most POS nodes are so expensive. If you have enough money to run them you can do anything else like POW mining or lending money to people for a profit. The main problem for a new investor is to have the money to invest. If you got enough running a node is one of the least profitable things you can do.