You might be more likely to quit for good if you use a mix of different methods, for example, using both a nicotine patch and gum may be better than a patch alone. othet helpful combinations include behavioral therapy and nicotine replacement therapy; prescription medication with a nicotine replacement therapy patch; and a nicotine replacement therapy patch and nicotine spray. The FDA hasn't approved using two types of nicotine replacement therapies at the same time, so be sure to talk with your doctor first to see if this is the right approach for you.,