I think that's the point - if you know how some market members are acting, you can play them. The easiest way I see lies in the combination with the autosell functionality of Cryptsy - other exchanges have probably similar mechanisms in place...

My impression is that the autoselling feature offers the coins at a price a tiny bit below the lowest offer. As an Altcoin-Collector / Investor you do the following:

• Watch Altcoins with a high spread (selling price is higher than buying price)
• If a pool comes in autoselling you notice it by the arrival of new sale offers (each asking for a price a little bit lower)
• Place a buy offer, offering a little bit more than the current highest bidder
• Offer coins for sale (a little bit higher than your rebuy bid)
• The next autosold coins will be offered at a price *below* your offer. Simply wait for the cheap coins coming in and gobble them up

In a bear market as right now you will probably simply wait for the cheap offers, but in a bull market I think you can play the autosellers like described above. Practically this mechanism seems to be in place, even if unvoluntarily...