If you want to reach not-too-savvy people I think a guide needs to be written how to get it up and running on Mac since bsddb is broken in (at least) Snow Leopard (I believe Leopard as well, haven't tried Lion).
Dumping related commands from my bash history, but I had Macports installed since before. The following
should be tested by someone who hasn't installed Macports or pywallet, on a clean install. It's just from memory/history.
Mac pywallet installation guide:
sudo port install python27 python_select
sudo python_select python27
sudo port select --set python python27
sudo port install py-bsddb
sudo port install py27-twisted
./pywallet.py
(yeah python_select might be overkill if the user is never going to install other python versions)
I forgot I have a Snow Leopard VM...... I'll test that there