you need to sit down and think about what you are trying to do with your coins. for example lets say you have 10BTC, what will you do with it?
if you just want to store 10BTC away for  more than a year and not touch it then a form of paper wallet is more suitable choice. and by that i mean a laminated paper or printing/etching the keys on a metal or a more resilient medium.

but if you are a day trader wanting to send that 10BTC back and forth to exchanges then a hardware wallet is more suitable for you because it is safe but at the same time  you can use it often.

or if you want to use it to make purchases, then you won't really do it with 10, you do it with smaller so put that smaller amount (like 0.1BTC) in a place where you can access it easily. it can be your desktop wallet, your phone or if you really needed it a web wallet but that should be the last resort.