It depends what you mean be profitable. Because they're old coins Im guessing you mean profitable to be traded, where in this cause profit is purely driven by demand. If the dev team is active or had produced a coin with real life use then the demand can be measured. Check the coins that have left the top 200 and ask yourself, is the coin in demand for real life use? or was it only speculative and the team is no longer active.
When I have time,  i like to do this analysis. I can honestly tell you there is much to learn from a studying failed(ing) projects than sometimes is the successful ones.