The most reliable one is ETH I suppose and the safest one is Monero. I am sure that Monero is the most anonymous alt coin that we have now, there is not another competitive one on the cryptomarket yet, and about ETH it is clear I consider.
For me no other than Ethereum most reliable and safe one, it is tested and trusted of many people. Also ETH have huge potential to increase much more and become more profitable when years passed by. Even its having a not good price right now, I still believe to it because I know it will recover soon. And throughout the year it remain listed as one of the most have potential and one of the most profitable.