Whatever "magic" happened for you it didn't happen for me. I've had P2PoolExtendedFrontEnd installed for a while and still seeing these timeout errors.
2014-01-17 08:49:06.336406 > Unhandled error in Deferred:
2014-01-17 08:49:06.336631 > Unhandled Error
2014-01-17 08:49:06.336702 > Traceback (most recent call last):
2014-01-17 08:49:06.336760 > Failure: twisted.internet.defer.TimeoutError: in ReplyMatcher
What does "ReplyMatcher" do?
ReplyMatcher matches replies to messages sent to bitcoind with responses. It's only used for the get_block_header message, and this error means that bitcoind didn't reply ... either it timed out or bitcoind doesn't have the header in question. So it could suggest that your Bitcoin node is slow or not up-to-date.. but seeing these rarely is normal.