I use Trezor with Electrum when the mempool gets a little bigger so I can use RBF

It's very safe to use hardware wallet with Electrum as long as you follow the instructions for the hardware wallet.
I've never tried multisig and won't bother I personally don't have the need for it anyway.
yeah i guess my paranoid self thinks if for some reason ledger or trezor gets compromised, the odds of both of them compromised at the exact same time is close to 0
maybe im just being super paranoid lol