I would say Coinbase is the only insured exchange. Although Binance has proven itself to be safe through guardrails they implemented to catch abnormal activity. We  saw sys abnormal activity and hiw their safu mechanism responded in timely manner.
July 3rd at 8:44 PM UTC
The price of SYS shoots up to from 0.0004 BTC to 96 BTC.
July 3rd at ~9:00 PM UTC
Binance shuts down the exchange for unscheduled maintenance.
July 3rd ~ 11:00 PM UTC
Binance resets all API keys as a security precaution.
July 4th ~ 12:00 AM UTC
Binance re-enables API key creation.
July 4th ~ 4:00 AM UTC
Binance completes system maintenance.
July 4th ~ 6:00 AM UTC
These are pretty fast response times for attack that was very well thought out.
Safest way is cold storage hw wallet but binance is not bad either..