Really they have not lost anything if the purpose was to purchase the underlying.   Did the network or protocol fail in those cases, if not then it was either not an investment to them as stated or they have not made a loss.

Seems almost everyone calls it investment but actually means I wanted a price to rise for something I never wanted to own.    This explains why the price rose so much and came down just that amount also.
I hope the overall crypto economy is developed enough that people popping in and out like this has some positive effects to the underlying business that blockchains process and transactions serviced

Most people I know just notice the price.   I've yet to hear much reaction to actual work done by blockchain, if I found people using a product and finding it especially useful to them then I would become very bullish on this regardless of price.