Very hard to mitigate the system risk. Invest small percentage into the larger and more proven coins such as btc, eth, etc. Be ready to pull the plug if you feel that things go the other way.
Behave like you are trading stock options. Which means expiration time, time value, news driven, etc.
Exactly high investments means that there is a high risks as well as high profits. But the best advice I can give is that you dont invest all that you have in cryptocurriences.