the highest lost that i've made as a gambler is 50$ , actually for me it's a big amount already so that was the biggest amount i lose in gambling and that time i was so frustrated but as days passed by i still go back to gamble.
Losing hard earned money is so frustrating. In general 50$ is not a big amount for regular gamblers. As you consider it as big amount, my advise is to stay away from gambling. You can lose more than that in a matter of time.