Well gambling legends are already able to estimate the frequency to which their hand is likely to be beaten, in the end, having the best cards enables you to win more frequently with a no bluff strategy, but you can definitely bluff your way to a win if you get a few favorable positions to do so.

Personally, I tend to play a mixture of both, bluff when I have a good opportunity into a set I know the opponent doesn't have.

For those that are interested, there are actually mathematically opportune moments to bluff if certain cards come down on the flop, turn and river, if you memorize the combinations and number of players at the table and compare it to the charts you'll be able to determine if you have an ample opportunity to bluff.

See this for more information - https://www.cardschat.com/bluffing.php