When I run into this I do 2 things. I try to educate them, by directing them to a topic I created
[Tips] Posting techniqueWhether it ever gets read that's a different story, I then usually follow it up with a good old "Report to moderator" asking them to trim the nested quote. I got the idea from the mining section as I noticed some threads were cleaned up nicely by this.
To each there own, I don't blame people for ignoring these posters and their lack of awareness. I'm on here for long enough stretches browsing at times where there is no discussion I want to be a part of atm, so I take a minute or two. I wrote the topic because it drove me crazy watching people quote massive posts several times over.