Is it still possible to start and run a Gambling site without a License?
Of course!
In case of cypto currencies the payment processor blockchain does not ask for a license and over 90% percent of the bettors do not care whether or not a sportsbook has one.
They also do not care to register its accounts with Game Protect and play with consumer protection service inclusive instead of register directly at random sportsbooks and moan in forums after got scammed.