Currently all mayor altcoin followed price action of Bitcoin, when Bitcoin crash or push, others altcoin also will do the samething with biggger volatility. In my opinion will be more profitable if we trade altcoin with stable coin than trade altcoin with Bitcoin. And on the crypto market right now many exchange offer trading pair altcoin with stable coin.
Apart from Ethereum the prices of almost all Altcoin are very low and you may not be able to make profits from those coins. Therefore it is better for you to trade in Ethereum. Its price is good and if there is a bit increase in the price you may make good money from it, not guaranteed but possible. The best option is only bitcoin for best trading and making money.