[...]  PoW mining is an economic activity.  You have capex, you have opex, almost all your profits are burned in your huge costs, and you have to care about efficiency in order to stay in the game.  And in any economic activity, you have economy of scale.  As your mining farm gets bigger, it becomes more efficient and stands better against the competition.  You get volume discounts for miners, you will be the first in line for the new generation of miners, you can get cheaper electricity when you buy wholesale, it becomes worthwhile to relocate to a more favorable location, and you can hire the best talent in the industry.  It doesn't matter if the PoW algorithm is ASICable or not, the economy of scale is universal.  It might be not very important in the growing market when everyone, even a smaller and weaker miner, gets a portion of the growing pie, but nothing lasts forever and as the market matures and gets more competitive, the weaker players are darwinized, and the hash power gets concentrated in the hands of a few bigger miners.  Miners, not mining pools.  This looks like an end-game of any PoW based blockchain, because it has a heavy "hook" into the economy, and the economy favors scale.  You can call it emergent centralization.  Incidentally, Byteball moves in the opposite direction.