After days of problems with one of the cards overheating the following settings work best for me.
Especially since the cards are not cheap i think everyone would like to get the maximum from their card without exhausting it so it will last more then a few months
--scrypt --gpu-dyninterval 7 --shaders 2048 --vectors 1 --lookup-gap 2 --thread-concurrency 11200 -g 2 -I 13 -w 256 --auto-fan --gpu-fan 30-75 --temp-cutoff 90 --temp-overheat 85 --temp-target 75 --gpu-memclock 1500 --gpu-engine 1080 --gpu-powertune -20 --expiry 1 --scan-time 1 --queue 0 --no-submit-stale
*Some coins seem to work better with thread concurrency 8192.
*Powertune works better on -20 then it does on +20.
This info is free as it should be but donations/tips are always welcome

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bitcoin@1Du9DFKtMFaVz4hFW1FGpRamcdYzkGTAFW
litecoin@LdNz7mvNn7Swyym8Uj53mMr87oJTpcmgtK
noblecoin@9URzRiG8eX7x9X1uZWXmDzmPqJS61Wfckp