It seems to me more profitable to deal with large investors, perhaps I am mistaken.
Of course. For any startup, its convenient to use money to develop from one source. No hassles to raise funds. But in most cases, projects do not find money from a single large investor.
There are cases when large investors do not pay much attention to the new project, while medium and small investors are ready to buy tokens of this team. So you should not turn away from these investors.
It is rightly noticed, sometimes it happens that the project is interesting only to small investors due to its specificity.