real world use cases would be #1

in fact this one is so large as to trump all the other by a large margin

lightning development is progressing very well and hopefully will be in use within the next 2-3 years on a large scale where you can buy all kinds of random things. use it on amazon, ebay etc. low cost true digital cash. the other thing is an easy use case. ideally banks would be able to function like exchanges. if you have $5000 in your checking a simple button click could convert xx dollars to btc and from there you could send it on chain or via lightning to the destination.  companies like western union have no place even existing if the world actually realized how bitcoin worked...however, values probably need to stabilize and that would mean an end to these 80+ % boom and bust cycles we keep having. maybe we can get some stability on the next run higher?

other things i would like to see in no real order

2. the death of bcash.
3. better custody solutions for the average person.
4. bad actors / scammers pushed from the space, hunted down etc
5. an established solution with gov regulators that will allow the industry to push aside worries about intervention