For me, I would rather be a flawed natural person than a "perfect human"，because I think that people who are transformed by science and technology will lose their souls, I am afraid of losing my soul.
What if today they offer you a scientifically proven, safe drug that stops you from aging and prevents you from getting any disease ever again. (Basically you will always be healthy) You would not take it?
This genetic manipulation has nothing to do with your soul, it is your body that receives the full benefits.