Of course you can, and it's not even hard, but you need to use leverage and you need an aggregate market to actually exist.  If there's no aggregate market, TA is a lot less useful and your only option is trying to determine what the tape painter/market rigger is doing.  Sometimes that can be even easier, sometimes a lot harder.  

The ONLY thing that holds me back in shitcoin trading is not that it's difficult to do, it's that there are NO TRUSTWORTHY EXCHANGES that you can put money on that have margin trading.  Who cares if you can make +5% or more per day trading shitcoins if at any second Bitfinex, Bitmex, or OKcoin will just steal your money leaving you down -100% instead of up anything.  Not that any trader with 2 braincells would trade on a rigged bucketshop like Bitmex in the first place.  And shitholes like Bitfinex are also rigged bucketshop casinos in practice.

Even if you attempt to trade non-margin on a supposed 'trustworthy' exchange like Coinbase, every time you log in they start asking you questions like "where did this money come", "prove to us where this money came from or we're going to freeze your account and take it", etc.