This thread might be of help to crypto gamble companies so they can work on those disadvantages and make your experience in gambling with cryptocurrency more fun and enjoyable.
1. I do see most gamblers are not satisfied with transparency of gambling houses hence a better system than "provably fair" may convince them at some levels.
2. More P2P games. I am well aware of practical limitations of P2P environment. Still, I do see many gamblers are demanding it compared to playing against house.
3. Quick and effective customer support. Even tier-1 houses are now a days replying, waiting for "higher people" to conclude.
4. Well defined TOS. No case to case rules.
5. Enhanced mobile gambling experiences. Gambling on the go is biggest demand for many people here.
Nice things, a new gambling house may take note of these. But, I feel OP is asking about disadvantages of crypto related gambling project. For that simple answer is losses and addictions but I wonder what a gambling house will do on that. Hence, I guess OP must need to edit the subject-line to something which will be appropriate for improving a gambling house.
@OP
I understand you are misusing the term "disadvantage" instead of "inconveniences" or "uncomfortable". If you edit both open-post and subject-line accordingly, I guess this topic may bring more useful things to this community and to crypto-gambling industry too.