lower intensity on at least one card to reduce system lag or overtaxing of the os
you can set the intensity like this    -d 0,1  -i 3,6        a batch file using 2 cards with diff intensities  may look like the one below

CryptoDredge  -a skunk  -d 0,1  -i 3,6 -o stratum+tcp://us.bsod.pw:2560 -u KRJdqqsTebT66sUj7T1duP64AB6pP7rQfj -p m=solo

or 10 cards may look like this

t-rex -a skunk  -d 0,1,2,3,4,5,6,7,8,9   -i 18,20,20,20,20,20,20,21,21,21  -o stratum+tcp://us.bsod.pw:2560 -u KRJdqqsTebT66sUj7T1duP64AB6pP7rQfj -p m=solo

remember the more cards the more ram youl need. for 10 gtx 1080 tis = 88gigs ram plus your ram add the total  = in vram to reduce possibility of crashing.

cheers i hope this helps